Depression, Obsessive Compulsive Disorder & Perfectionism Revealed

By Samantha Gilbert, FNC, CHNP, CNC     Last updated on October 22nd, 2021

We’re all familiar with histamine, especially as it relates to allergies. According to the Asthma and Allergy Foundation, an estimated 50 million Americans suffer from allergies, and they’re the fifth leading chronic disease in the U.S.

But what if I told you there’s more to histamine than just allergies, asthma, and hives?

What is Histamine?

Histamine is a physiologically active amine that is found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. It stimulates gastric secretion, causes dilation of capillaries, constriction of bronchial smooth muscle, decreased blood pressure, and also functions as a neurotransmitter.[1]

Yep, that’s right. A neurotransmitter.

Histamine and Mental Health

As a neurotransmitter, histamine influences mood, appetite, sleep and thought.

When elevated (called undermethylation), histamine causes depression, obsessive compulsive disorder (OCD), and perfectionism[2]. Disordered eating typically has an undermethylated profile. Simple blood tests are all that’s required to determine methylation status.

We now know there’s a biochemical reason we read our emails 12 times in a row and get really irritated when the Christmas tree leans over one-sixteenth of an inch. Whether it’s drugs, alcohol, food, sex, or gambling. All addictions share a common theme: imbalanced biochemistry.

When histamine is too low (called overmethylation), there is a tendency for high anxiety, panic disorder, depression, and food and chemical sensitivities.

Overmethylation is correlated with Obsessive Compulsive Personality disorder (OCPD), while undermethylation is correlated with traditional OCD. The latter usually only covers one or two obsessions, while the former is generally obsessive compulsive in most areas of their lives.

Treating Histamine Imbalance

Like gluten intolerance, merely staying away from high histamine foods does not address the underlying problem. In both scenarios, there is an imbalance of Metallothionine (MT), which are cysteine-rich proteins with powerful antioxidant capabilities. MT proteins also perform a wide variety of vital functions including (but not limited to):

  • Detoxification of mercury and other toxic heavy metals
  • Development and functioning of the immune system
  • Delivery of zinc to cells throughout the body
  • Prevention of yeast overgrowth (SIBO and dysbiosis are both linked to over and undermethylation)
  • Regulation of stomach acid pH
  • Taste discrimination by the tongue
  • Protection of enzymes that break down casein and gluten
  • Enhanced efficiency of the intestinal and blood-brain barriers
  • Reduction of inflammation after injury or illness[3]

If you know of someone who struggles with addiction or depression, please share this post. If you struggle, please share your experience in the comments below. It is through sharing your story that we create community, eliminate guilt and shame, and bring about healing.


[1] Walsh, William J. (2012). Nutrient Power: Heal Your Biochemistry and Heal Your Brain. (173). New York, NY: Skyhorse.
[2] Mensah, Albert. Bowman, Judith. Retrieved from personal treatment protocol.
[3] Walsh, William J. (2012). Nutrient Power: Heal Your Biochemistry and Heal Your Brain. (190). New York, NY: Skyhorse.


20 thoughts on “Depression, Obsessive Compulsive Disorder & Perfectionism Revealed”

  1. Sami, thank you for sharing all your knowledge I’ve learned so much. I am considered an undermethylator and am homozygous for the mthfr 6779 gene. I have horrible depression for a good portion on my life and respond pretty good to SSRIs besides the side effects. Anyway I know methylfolates make my depression worse from research and trial and error but I started using SamE and it really seems to help my depression. I’m just curious about the dosing range? Also, is it possible to cause some start up symptoms or anxiety because your body hasn’t made a lot for a long time and is not used to it? I started with 200 mg And noticed nothing but with 400 mg my depression is already very lessened but if feels like I drank 3 cups of coffee, maybe my body needs time to adjust? Thank u!!!

    1. You’re very welcome, Michael. Please be careful with nutrients until you are properly tested. Despite all the propaganda, genetic testing such as MTHFR has no way of determining methylation status because there are mutations for both over and undermethylation and we have no way of knowing which way they go. Dosing is determined after a consultation and proper labs.

  2. I have had ocd for 50 years, awhile back i started taking Carlsons Tri B, a combo of b6, b12, and folic acid, after reading these vitamins prevent gray matter from shrinking in relation to Alzheimer’s, I started taking Tri B to prevent this shrinkage, and much to my surprise, my ocd essentially disappeared after 4 to 5 weeks. I started doing research as to why this happened, and learned about one carbon metabolism in ocd, and high homocysteine, which prevents brain from breaking down glutamate, a major player in ocd. Only get your info about mental disorders from neuroscientists, average psychiatrists are doctors weak in the hard sciences, so they gravitate towards the softest branch of medicine – psychiatry, where they are not even required to have a doctorate in psychology, most psychiatrists are involved in a conflict of interest, where they are financially motivated to support drug company interests, they will withhold such info from you regarding natural treatments. With drugs, they are merely treating the downstream effects of ocd, rather than the root cause, strictly for profit. Only unnatural means of treating ocd are profitable.

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