Undermethylation

What is undermethylation?

Undermethylation (also called histadelia) is a condition that occurs when too few methyl molecules are available to add to enzymes, hormones, and neurotransmitters. We receive our methylation status in utero. Undermethylation is not the same condition as histamine intolerance or Mast Cell Activation Syndrome (MCAS). 

Why is it a problem?

Lack of methyl groups (a carbon group with three hydrogen atoms) to support neurotransmitter activity creates depressed levels of serotonin, dopamine, and norepinephrine. Suboptimal levels of these important neurotransmitters cause depression, perfectionism, obsessive-compulsive and ritualistic behaviors, addictive tendencies, high-achievement and competition, and seasonal allergies. Undermethylators tend to respond well to serotonin-enhancing substances such as Prozac, Zoloft, St. John’s Wort, and SAMe. These individuals are also more at risk to develop certain types of cancers.

Until recently, schizophrenia was seen in our overmethylation population, but we are now seeing quite a few undermethylation cases. According to my personal physician, Dr. Albert Mensah of Mensah Medical, one possible cause could be the liberal use of folic acid before, during, and after pregnancy. Folic acid decreases the presence of methyl in our DNA. This can be of great benefit to overmethylated individuals, but can create significant challenges for those who are undermethylated. Because folic acid is a common component of prenatal vitamins, and because we have no way of knowing the methyl biotype of a fetus while in utero, prolonged use of prenatal vitamins could actually be preselecting undermethylated children for increased risk of developing schizophrenic symptoms at some point in their lives. Please note research is currently under way on this clinical trend we are seeing.

Who can be undermethylated?

I often see high achieving, type A individuals with strong perfectionistic tendencies to be undermethylated. They are calm on the outside with lots of inner tension and often, severe depression. Undermethylation is also an underlying component of autism.

How can we fix it?

Undermethylators have a genetic tendency to be very low in calcium, magnesium, methionine, and vitamin B6, with excessive levels of folate. This condition can be safely corrected and balanced with dietary and nutrient therapy, as well as lifestyle modifications. First, let’s see if you might be impacted by this. Take my free, five-minute life assessment to find out if this applies to you.

Undermethylation Articles

Breast Cancer, Methylation and Copper Toxicity
Copper Overload

Breast Cancer, Methylation and Copper Toxicity

Breast cancer, methylation, and copper toxicity share common links: Estrogen dominance/sensitivity, and a genetic inab...
Continue Reading ›
MTHFR Methylfolate vs. Folic Acid Facts and Myths
ADHD

MTHFR Methylfolate vs. Folic Acid Facts and Myths

In today's post, Dr. Albert Mensah and I address the facts and myths surrounding MTHFR methylfolate, folic acid, and f...
Continue Reading ›
Dangers of Folic Acid Supplements while Pregnant
ADHD

Dangers of Folic Acid Supplements while Pregnant

Folic acid supplementation is not one size fits all for pregnant women. In addition, women should not presume that whi...
Continue Reading ›
Methylation Diet Tips: Are you eating right for your biotype?
ADHD

Methylation Diet Tips: Are you eating right for your biotype?

Methylation Diet Tips: Are you eating right for your biotype? I'm so glad July is almost over. It's been a crazy mont...
Continue Reading ›
Histamine Intolerance: Methylation, Gut & Copper Connection
ADHD

Histamine Intolerance: Methylation, Gut & Copper Connection

If you think you may suffer from histamine intolerance or mast cell activation syndrome (MCAS) and are looking for ans...
Continue Reading ›
The Underlying Cause of OCD/Perfectionism and What To Do About It
ADHD

The Underlying Cause of OCD/Perfectionism and What To Do About It

The Underlying Cause of OCD/Perfectionism and What To Do About It. Picture this: you’re in college and you have to ...
Continue Reading ›
Folate: Friend or Foe?
ADHD

Folate: Friend or Foe?

Could folate be your friend or foe? Yesterday I was perusing my fitness magazines and couldn't help but notice all th...
Continue Reading ›
Depression, Obsessive Compulsive Disorder & Perfectionism Revealed
Depression/Anxiety

Depression, Obsessive Compulsive Disorder & Perfectionism Revealed

Histadelia, Depression, Obsessive Compulsive Disorder & Perfectionism Revealed. We're all familiar with histamine,...
Continue Reading ›
Methylation: What It Is And How It Affects You
ADHD

Methylation: What It Is And How It Affects You

Methylation is crucial to happiness and well-being. Making too much or not enough methyl impairs our ability to think...
Continue Reading ›

Undermethylation Podcast Episodes

EP 02: How Nutrient Deficiencies And Overloads Impact The Brain And Body
Podcast

EP 02: How Nutrient Deficiencies And Overloads Impact The Brain And Body

One month in, my client Amanda told me: “I had no idea my anxiety, racing thoughts, and fatigue were due to being se...
Continue Reading ›
EP 03: How Biochemistry and Genes Impact Your Brain with Dr. Albert Mensah, MD, BCIP
Podcast

EP 03: How Biochemistry and Genes Impact Your Brain with Dr. Albert Mensah, MD, BCIP

Our stories are extremely powerful and contain genetic, epigenetic, and transgenerational narratives.  Educating...
Continue Reading ›
EP 14: Breast Cancer and the Truth About Folic Acid in Cell Division with Dr. Albert Mensah
Podcast

EP 14: Breast Cancer and the Truth About Folic Acid in Cell Division with Dr. Albert Mensah

It's Breast Cancer Awareness Month.  This is a topic that’s near and dear to my heart because breast cancer ru...
Continue Reading ›

“Samantha is the most knowledgeable nutritionist I’ve worked with and has unique knowledge in the area of copper disorders and methylation. Her advice has helped me immensely in dealing with fibromyalgia and treatment-resistant depression.”

JOHN C.

Schedule a Free One-on-One Consultation

If you’re ready to start your healing journey, schedule your free one-on-one consultation to discuss your current mental and/or physical health challenges, history, and desired health goals. Take the first step on your healing journey today.

Scroll to Top
.