Overmethylation

What is overmethylation?

Overmethylation (also called histapenia) is a condition that occurs when too many methyl molecules are available to add to enzymes, hormones, and neurotransmitters. We receive our methylation status in utero.

Why is it a problem?

Too many methyl groups (a carbon group with three hydrogen atoms) creates excessive levels of the important neurotransmitters serotonin, dopamine, and norepinephrine, which leads to hyperexcitability in the brain. This causes high anxiety, rumination, heavy body hair, musical and artistic abilities, an inability to sit still, food and chemical sensitivities, paranoia, and sleeping problems. Overmethylators do not respond well to serotonin-enhancing substances such as Prozac, Zoloft, St. John’s Wort, and SAMe, which can make them suicidal. Bipolar disorder and schizophrenia are often seen in overmethylated individuals.

Who can be overmethylated?

Individuals with high empathy for others, food and chemical sensitivities, and an adverse reaction to antidepressant medications may be overmethylated. Verbosity is also a hallmark of this condition.

How can we fix it?

Overmethylators have a genetic tendency to be very low in folate and vitamin B6, in addition to other important nutrients. This condition can be safely corrected and balanced with dietary and nutrient therapy, as well as lifestyle modifications. First, let’s see if you might be impacted by this. Take my free, five-minute life assessment to find out if this applies to you.

Overmethylation Articles

Methylation Diet Tips: Are you eating right for your biotype?
ADHD

Methylation Diet Tips: Are you eating right for your biotype?

Methylation Diet Tips: Are you eating right for your biotype? I'm so glad July is almost over. It's been a crazy mont...
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Methylation: What It Is And How It Affects You
ADHD

Methylation: What It Is And How It Affects You

Methylation is crucial to happiness and well-being. Making too much or not enough methyl impairs our ability to think...
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Folate: Friend or Foe?
ADHD

Folate: Friend or Foe?

Could folate be your friend or foe? Yesterday I was perusing my fitness magazines and couldn't help but notice all th...
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MTHFR Methylfolate vs. Folic Acid Facts and Myths
ADHD

MTHFR Methylfolate vs. Folic Acid Facts and Myths

In today's post, Dr. Albert Mensah and I address the facts and myths surrounding MTHFR methylfolate, folic acid, and f...
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Overmethylation Podcast Episodes

EP 02: How Nutrient Deficiencies And Overloads Impact The Brain And Body
Podcast

EP 02: How Nutrient Deficiencies And Overloads Impact The Brain And Body

One month in, my client Amanda told me: “I had no idea my anxiety, racing thoughts, and fatigue were due to being se...
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EP 03: How Biochemistry and Genes Impact Your Brain with Dr. Albert Mensah, MD, BCIP
Podcast

EP 03: How Biochemistry and Genes Impact Your Brain with Dr. Albert Mensah, MD, BCIP

Our stories are extremely powerful and contain genetic, epigenetic, and transgenerational narratives.  Educating...
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“Sami’s guidance is cutting edge. She offers a unique perspective that is evidence-based and through proper testing helps to identify and uncovers any core imbalances within the body that are creating havoc. For me, deeper restoration and healing has finally come after 25 years of searching and trying a plethora of medications and dietary protocols. Before finding Sami I was uncertain if I could live another day. Sami is incredibly wise, knowledgeable, and empathetic; drawing from her large reservoir of training as well as her own personal experience. Sami’s ability to consult with Dr. Albert Mensah, a brilliant Physician in this field, is an added comfort and bonus. The healing process is not easy, but if you are willing to trust Sami’s guidance, and persevere with the dietary changes and daily nutrients, I feel confident that you can know greater health and freedom that is lasting.”

SYDNEY SYKES

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